Regenerative Medicine of Tomorrow

Scientific Insights into Spark Wave®
Therapy Applications

Bones
ESWT Promotes Fracture Healing and Bone Stability

Extracorporeal Shockwave Therapy (ESWT) is a clinically recognized regenerative treatment that promotes bone healing and regeneration. It works at a cellular and molecular level to stimulate osteogenesis, accelerate fracture healing and enhance bone stability. [3] [4] [5] [6]

How ESWT supports Bone Regeneration:

Induction of Bone Formation (Osteogenesis):

Activates endothelial nitric oxide synthase (eNOS), increasing nitric oxide (NO) production.

Nitric oxide promotes the differentiation and activity of human osteoblasts, the cells responsible for bone formation. 

Accelerated Fracture Healing:

Stimulates the expression of key growth factors and bone marrow proteins essential for bone repair. 

Enhances cellular communication within the fracture site to optimize the healing environment. 

[1] [2]

iological effects of ESWT on bone tissue. The increase of biological factors leads to stem cell differentiation, osteoblast

Biological effects of ESWT on bone tissue.

The increase of biological factors leads to stem cell differentiation, osteoblast activation and bone formation.

BMP, bone morphogenetic protein; TGF-β, transforming growth factor-β; RunX2, Runt-related transcription factor 2; Modified after Jing et al. [7] and Liu et al. [8]

KEY BENEFITS

Less burden, faster return to daily life

Non-invasive, regenerative treatment option

Accelerated bone repair of delayed union

Stimulation of healing progression in pseudarthrosis 

REFERENCES

Sun, D. (2013). Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors. Scientific Reports, 3, Article 2175
Koolen, M. K. E., Kruyt, M. C., Zadpoor, A. A., Öner, F. C., Weinans, H., & van der Jagt, O. P. (2018). Optimization of screw fixation in rat bone with extracorporeal shock waves. Journal of Orthopaedic Research, 36, 76–84.
Mittermayr, R., Haffner, N., Feichtinger, X., & Schaden, W. (2021). The role of shockwaves in the enhancement of bone repair: From basic principles to clinical application. Injury.
Dahm, F., Feichtinger, X., Vallant, S.-M., Haffner, N., Schaden, W., Fialka, C., & Mittermayr, R. (2021). High‑energy focused extracorporeal shockwave therapy in humeral delayed‑union and non‑unions. European Journal of Trauma and Emergency Surgery, 48(4), 3043–3049.
Furia JP, Juliano PJ, Wade AM, Schaden W, Mittermayr R. Shock wave therapy compared with intramedullary screw fixation for nonunion of proximal fifth metatarsal metaphyseal-diaphyseal fractures. J Bone Joint Surg Am. 2010 Apr;92(4):846-54.
Quadlbauer, S., Pezzei, C., Beer, T., Kolmayr, B., Jurkowitsch, J., Kolblinger, R., Hintringer, P., Hausner, T., Sadoghi, P., Leixnering, M., & Kralinger, F. (2023). Double screw versus angular stable plate fixation of scaphoid waist nonunions in combination with intraoperative extracorporeal shockwave therapy (ESWT). Archives of Orthopaedic and Trauma Surgery, 143(10), 6501–6511.
Jing, N.; Hou, Y.; Zhang, J.; Xu, G.; Lei, M.; Tang, X.; Chen, W.; Ni, H.; Zhang, F. Cracking the Code: Understanding ESWT’s Role in Bone Fracture Healing. Journal of Orthopaedic Translation 2025, 50, 403–412.
Liu, Z.; Wang, Q.; Zhang, J.; Qi, S.; Duan, Y.; Li, C. The Mechanotransduction Signaling Pathways in the Regulation of Osteogenesis. IJMS 2023, 24 (18), 14326.

Intended for use by healthcare professionals only and Indications are approved under MDD 93/42/EEC. Product availability, regulatory approvals, and certifications may vary by country. For detailed information regarding local availability and regulatory status, please contact your local sales representative.