Regenerative Medicine of Tomorrow

Scientific Insights into Spark Wave®
Therapy Applications

Sexual Health
ESWT Leads to Nerve Regeneration,
Vascularization and Pain Reduction

ESWT is an emerging, non-invasive treatment for sexual health concerns and urological indications, including Erectile Dysfunction (ED), Chronic Pelvic Pain Syndrome (CPPS) and Peyronie`s disease. By targeting the underlying biological mechanisms rather than just the symptoms, ESWT offers a regenerative approach to reduce pain and restore sexual vitality/function. 

How ESWT Supports Urological Indications and Improves Sexual Health: 

Nerve Recovery:

Stimulates the production of nitric oxide (NO), which supports nerve repair and improves neural signaling, especially beneficial for diabetic-related ED.  

Vascular Stimulation & Improved Circulation:

Promotes the formation of new blood vessels and improves blood flow, which is crucial for erectile function and tissue health. 

Tissue Regeneration:

Activates cellular repair and promotes the growth of healthy tissue, improving overall tissue quality and function. [1]

Erectile Dysfunction (ED) :

ESWT promotes both nerve regeneration and vascularization, helping to restore the body’s natural erectile function. This approach aims to enable spontaneous, natural erections by addressing the root causes of ED, rather than relying solely on medications for temporary symptom relief. [2] [3]

Chronic Pelvic Pain Syndrome (CPPS) :

In CPPS, ESWT helps reduce pelvic pain, improve urinary symptoms, and enhance local blood circulation. These combined effects contribute to improved comfort, function, and overall quality of life.  [5] [6] [7]

Peyronie’s Disease (IPP) :

In Peyronie’s disease, ESWT can alleviate penile pain and support tissue remodeling processes. By influencing fibrosis and plaque-related changes, it may help slow disease progression and improve overall sexual well-being. [4] [8]

Schematic illustration of the molecular mechanism in erectile dysfunction and the effect of ESWT:

Reduced nitric oxide (NO) production lowers cyclic guanosine monophosphate (cGMP), opens Ca²⁺ -Channels and closes K⁺ -Chanels, this activates myosin and causes smooth muscle contraction preventing erection.

ESWT increases NO production, elevates cGMP, switches channel activity, inactivates myosin, and induces smooth muscle relaxation, enabling erection. [1][9]

Key Benefits

Restores natural sexual function

Reduces chronic pelvic pain

Improves blood flow and tissue quality

Non-invasive and drug-free solution

References

Qiu, X.; Lin, G.; Xin, Z.; Ferretti, L.; Zhang, H.; Lue, T. F.; Lin, C.-S. Effects of Low-Energy Shockwave Therapy on the Erectile Function and Tissue of a Diabetic Rat Model. The Journal of Sexual Medicine 2013, 10 (3), 738–746.
Goldstein, S. W.; Kim, N. N.; Goldstein, I. Randomized Trial of Low Intensity Shockwave Therapy for Erectile Dysfunction Utilizing Grayscale Ultrasound for Analysis of Erectile Tissue Homogeneity/Inhomogeneity. Transl Androl Urol 2024, 13 (10), 2246–2267.
Rubino, M.; Ricapito, A.; Finati, M.; Falagario, U. G.; Annese, P.; Mancini, V.; Busetto, G. M.; Cormio, L.; Carrieri, G.; Bettocchi, C. Impact of Low-Intensity Extracorporeal Shockwave Therapy on Vascular Parameters and Sexual Function in Patients with Arteriogenic Erectile Dysfunction. Asian Journal of Andrology.
Porst, H. Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED), Peyronie’s Disease (PD), and Sexual Rehabilitation After Radical Prostatectomy With Special Focus on Technical Aspects of the Different Marketed ESWT Devices Including Personal Experiences in 350 Patients. Sexual Medicine Reviews 2021, 9 (1), 93–122.
Birowo, P.; Rangganata, E.; Rasyid, N.; Atmoko, W. Efficacy and Safety of Extracorporeal Shockwave Therapy for the Treatment of Chronic Non-Bacterial Prostatitis: A Systematic Review and Meta-Analysis. PLoS ONE 2020, 15 (12), e0244295.
Kong, X.; Hu, W.; Dong, Z.; Tian, J.; Wang, Y.; Jin, C.; Liang, C.; Hao, Z.; Wang, Z. The Efficacy and Safety of Low-Intensity Extracorporeal Shock Wave Treatment Combined with or without Medications in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Systematic Review and Meta-Analysis. Prostate Cancer Prostatic Dis 2023, 26 (3), 483–494.
Labetov, I.; Vaganova, A.; Kovalev, G.; Shkarupa, D. Extracorporeal Shockwave Therapy in Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Systematic Review and Meta‐analyses. Neurourology and Urodynamics 2024, 43 (8), 1924–1937.
Li, G.; Xu, X.; Man, L. Low-Intensity Extracorporeal Shock Wave Therapy for Peyroniès Disease: A Systematic Review and Meta-Analysis. BMC Urol 2024, 24 (1), 217.
Dean RC, Lue TF. Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am. 2005 Nov; 32(4): 379–95.

Intended for use by healthcare professionals only and Indications are approved under MDD 93/42/EEC. Product availability, regulatory approvals, and certifications may vary by country. For detailed information regarding local availability and regulatory status, please contact your local sales representative.