Regenerative Medicine of Tomorrow

Scientific Insights into Spark Wave® Therapy Applications

Muscle and Tendons
ESWT Reduces Pain & Inflammation and Promotes Tissue Repair

Extracorporeal Shockwave Therapy (ESWT) is a clinically proven, non-invasive treatment that supports the repair and regeneration of muscle and tendon tissues. Studies show up to a 81.5 % success rate in treating chronic tendinopathies, making ESWT a leading choice for musculoskeletal rehabilitation. [3]

How ESWT Works on Muscle and Tendon Tissue:

Pain Reduction through Nerve Desensitization:

Decreased concentration of Substance P, a key pain mediator, and desensitized nerve fibres result in rapid and long-lasting pain relief.

Enhanced Blood Flow & Vascular Growth:

Stimulates angiogenesis (the formation of new blood vessels), improving circulation and oxygen delivery to injured tissues. This acceleration of nutrtion transport and waste removal is essential for healing.

Cellular Regeneration & Collagen Remodeling:

Activates cell proliferation and stem cell activity, promoting increased collagen synthesis. This not only repairs damaged fibers but also improves tissue structure through targeted collagen remodeling.

Inflammation Modulation:

Influences macrophage activity, helping to regulate inflammatory processes. This targeted immune response reduces swelling, alleviates pain, and speeds up tissue repair.

[1] [2]

Main biological effects of ESWT on tendon tissue.

The increase of biological factors leads to higher cell activity as well as collagen and blood vessel formation.
NO, nitric oxide; IL-6, interleukin-6; TGF-β, transforming growth factor-β; PCNA, proliferating cell nuclear antigen; IGF-1, insulin-like growth factor-1; VEGF, vascular endothelial growth factor; eNOS, endothelial nitric oxide synthase. Modified after Chen et al. [2] and Poenaru et al. [1]

Key Benefits

Proven clinical success in muscle and tendon recovery

Accelerated healing and reduced downtime

Non-invasive and drug-free treatment option

Improved tissue quality and long-term function

References

Poenaru, D., Sandulescu, M. I., & Cinteza, D. (2023). Biological effects of extracorporeal shockwave therapy in tendons: A systematic review. Biomedical Reports, 18, 15.
Chen, Y. (2022). Biological response of extracorporeal shock wave therapy in tendon repair: A comprehensive in vivo review. Frontiers in Veterinary Science.
Fansa, A., Talsania, A. J., Kennedy, J. G., & O’Malley, M. J. (2021). Efficacy of unfocused medium‑intensity extracorporeal shock wave therapy (MI‑ESWT) for plantar fasciitis. Journal of Foot & Ankle Surgery, 60(3), 471–476.
Auersperg, V., & Trieb, K. (2020). Extracorporeal shock wave therapy: An update. EFORT Open Reviews, 5(10), 584–592.
Rhim, H. C., Shin, J., Kang, J., Dyrek, P., Crockett, Z., Galido, P., Wade, C., Hollander, K., Borg‑Stein, J., Sampson, S., & Tenforde, A. S. (2024). Use of extracorporeal shockwave therapies for athletes and physically active individuals: A systematic review. British Journal of Sports Medicine, 58(3), 154–163.
Avendaño‑López, C., Megía‑García, Á., Beltrán‑Alacreu, H., Serrano‑Muñoz, D., Arroyo‑Fernández, R., Comino‑Suárez, N., & Avendaño‑Coy, J. L. (2024). Efficacy of extracorporeal shockwave therapy on pain and function in myofascial pain syndrome: A systematic review and meta‑analysis of randomized clinical trials. American Journal of Physical Medicine & Rehabilitation, 103(2), 89–98.

Intended for use by healthcare professionals only and Indications are approved under MDD 93/42/EEC. Product availability, regulatory approvals, and certifications may vary by country. For detailed information regarding local availability and regulatory status, please contact your local sales representative.